Biosafety Level-3 laboratories (BSL-3) are an essential part of research infrastructure and are used to develop vaccines and therapies. The research conducted in them provides insights into host-pathogen interactions that may help prevent future pandemics. However, these facilities also potentially pose a risk to society through lab accidents or misuse. Despite their importance, there is no comprehensive list of BSL-3 facilities, or the institutions in which they are housed. By systematically assessing PubMed articles published in English from 2006-2021, this paper maps institutions that host BSL-3 labs by their locations, augmenting current knowledge of where high-containment research is conducted globally.

Geopolitical tensions between the United States and China have sparked an ongoing dialogue in Washington about the phenomenon of “decoupling”—the use of public policy tools to separate the multifaceted economic ties that connect the two powers. This issue brief provides a historical lens on the efficacy of one specific aspect of this broader decoupling phenomenon: using export controls and related trade policies to prevent a rival from acquiring the equipment and know-how to catch up to the United States in cutting-edge, strategically important technologies.

China is banking on applying AI to biotechnology research in order to transform itself into a “biotech superpower.” In pursuit of that goal, it has emphasized bringing together different aspects of the development cycle to foster multidisciplinary research. This data brief examines the emerging trend of co-location of AI and biotechnology researchers and explores the potential impact it will have on this growing field.

China’s "Science and Technology Daily," a state-run newspaper, published a revealing series of articles in 2018 on 35 different Chinese technological import dependencies. The articles, accessible here in English for the first time, express concern that strategic Chinese industries are vulnerable to any disruption to their supply of specific U.S., Japanese, and European “chokepoint” technologies. This issue brief summarizes the article series and analyzes the Chinese perspective on these import dependencies and their causes.

CSET Research Fellow Caroline Schuerger testified before the Bipartisan Commission on Biodefense hearing on "The Biological Threat Expanse" Current and Future Challenges to National Biodefense." She discussed threats to the bioeconomy and steps the U.S. and its allies can take to harness biotechnology's capabilities and raise awareness of risky research.

This data brief explores how international collaboration relates to the impact and output of research publications. Focusing on the top 10 countries with the highest publication output from 2010 to 2019, the authors provide a comprehensive analysis across the major fields of science and technology.

Militaries around the world have often relied on the largest global defense companies to acquire and integrate cutting-edge technologies. This issue brief examines the investment and mergers and acquisition activities in artificial intelligence of the top 50 global defense companies — a key, if limited, approach to accessing AI innovation in the commercial sector — and assesses investment trends of their corporate venture capital subsidiaries and offers a geographic breakdown of defense companies and their AI target companies.

As U.S. policymakers grapple with the need to control international technology flows, this annotated bibliography distills key lessons and surveys 50 years of scholarship, government documents, and commentary. The resources it presents are at the intersection of international economics and technology and span from the Cold War to the current challenges surrounding U.S.-China relations.

Conventional wisdom suggests that cutting-edge artificial intelligence is dependent on large volumes of data. An overemphasis on “big data” ignores the existence—and underestimates the potential—of several AI approaches that do not require massive labeled datasets. This issue brief is a primer on “small data” approaches to AI. It presents exploratory findings on the current and projected progress in scientific research across these approaches, which country leads, and the major sources of funding for this research.

As dual-use technologies transform the national security landscape, the U.S. Department of Defense has established a variety of offices and programs dedicated to bringing private sector innovation into the military. However, these efforts have largely failed to drive cutting-edge commercial technology into major military platforms and systems. This report examines the shortcomings of the DOD’s current approach to defense innovation and offers recommendations for a more effective strategy.