Recent government directives, international conferences, and media headlines reflect growing concern that artificial intelligence could exacerbate biological threats. When it comes to biorisk, AI tools are cited as enablers that lower information barriers, enhance novel biothreat design, or otherwise increase a malicious actor’s capabilities. In this explainer, CSET Biorisk Research Fellow Steph Batalis summarizes the state of the biorisk landscape with and without AI.

CSET submitted the following comment in response to a Request for Comment (RFC) from the Office of Management and Budget (OMB) about a draft memorandum providing guidance to government agencies regarding the appointment of Chief AI Officers, Risk Management for AI, and other processes following the October 30, 2023 Executive Order on AI.

Demand for talent is one of the core elements of technological competition between the United States and China. In this issue brief, we explore demand signals in China’s domestic AI workforce in two ways: geographically and within the defense and surveillance sectors. Our exploration of job postings from Spring 2021 finds that more than three-quarters of all AI job postings are concentrated in just three regions: the Yangtze River Delta region, the Pearl River Delta, and the Beijing-Tianjin-Hebei area.

Antimicrobial resistance (AMR) is one of the world’s most pressing global health threats. Basic research is the first step towards identifying solutions. This brief examines the AMR research landscape since 2000, finding that the amount of research is increasing and that the U.S. is a leading publisher, but also that novel solutions like phages and synthetic antimicrobial production are a small portion of that research.

This report summarizes recent DOD digital workforce trends as an update to our 2021 report. We expanded our definition of AI talent to include data, analytics, software, and AI, referred to here as the “digital workforce,” to be more aligned with Department needs and current workforce planning efforts. We find that the Department of Defense continues to struggle with their ability to define, identify, develop, assign, promote, and retain digital talent.

How can policymakers credibly reveal and assess intentions in the field of artificial intelligence? Policymakers can send credible signals of their intent by making pledges or committing to undertaking certain actions for which they will pay a price—political, reputational, or monetary—if they back down or fail to make good on their initial promise or threat. Talk is cheap, but inadvertent escalation is costly to all sides.

CSET submitted the following comment in response to a Request for Information (RFI) from the White House's Office of Science and Technology Policy about potential changes to the Policies for Federal and Institutional Oversight of Life Sciences Dual Use Research of Concern (DURC) and Recommended Policy Guidance for Departmental Development of Review Mechanisms for Potential Pandemic Pathogen Care and Oversight (P3CO).

Australia, Canada, Japan, the United Kingdom, and the United States emphasize principles of accountability, explainability, fairness, privacy, security, and transparency in their high-level AI policy documents. But while the words are the same, these countries define each of these principles in slightly different ways that could have large impacts on interoperability and the formulation of international norms. This creates, what we call the “Inigo Montoya problem” in trustworthy AI, inspired by "The Princess Bride" movie quote: “You keep using that word. I do not think it means what you think it means.”

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Gain- and loss-of-function research have contributed to breakthroughs in vaccine development, genetic research, and gene therapy. At the same time, a subset of gain- and loss-of-function studies involve high-risk, highly virulent pathogens that could spread widely among humans if deliberately or unintentionally released. In this report, we map the gain- and loss-of-function global research landscape using a quantitative approach that combines machine learning with subject-matter expert review.