There’s a lot to digest in the October 30 White House’s AI Executive Order. Our tracker is a useful starting point to identify key provisions and monitor the government’s progress against specific milestones, but grappling with the substance is an entirely different matter. This blog post, focusing on Section 4 of the EO (“Developing Guidelines, Standards, and Best Practices for AI Safety and Security”), is the first in a series that summarizes interesting provisions, shares some of our initial reactions, and highlights some of CSET’s research that may help the USG tackle the EO.

Antimicrobial resistance (AMR) is one of the world’s most pressing global health threats. Basic research is the first step towards identifying solutions. This brief examines the AMR research landscape since 2000, finding that the amount of research is increasing and that the U.S. is a leading publisher, but also that novel solutions like phages and synthetic antimicrobial production are a small portion of that research.

In an op-ed published in Foreign Policy, CSET’s Steph Batalis discusses the potential misuse of artificial intelligence chatbots in providing instructions for the construction of biological weapons.

CSET submitted the following comment in response to a Request for Information (RFI) from the White House's Office of Science and Technology Policy about potential changes to the Policies for Federal and Institutional Oversight of Life Sciences Dual Use Research of Concern (DURC) and Recommended Policy Guidance for Departmental Development of Review Mechanisms for Potential Pandemic Pathogen Care and Oversight (P3CO).

In their op-ed featured in Think Global Health, CSET's Steph Batalis and Caroline Schuerger provide expert analysis on the ongoing debate in the United States regarding gain-of-function (GOF) research.

In a Washington Post article that delves into China's extensive efforts to collect genetic data from around the world, using innovative technology, CSET's Anna Puglisi provided her expert insights.

CSET's Anna Puglisi was featured in a Nature article along with a report she co-authored. The article discusses the challenges faced by US policymakers in regulating research involving potentially harmful pathogens. The focal point of the discussion is the CSET report titled “Understanding the Global Gain-of-Function Research Landscape.”

Gain- and loss-of-function research have contributed to breakthroughs in vaccine development, genetic research, and gene therapy. At the same time, a subset of gain- and loss-of-function studies involve high-risk, highly virulent pathogens that could spread widely among humans if deliberately or unintentionally released. In this report, we map the gain- and loss-of-function global research landscape using a quantitative approach that combines machine learning with subject-matter expert review.

CSET's Anna Puglisi was cited in an article by CNN that delves into China's efforts to become a global leader in the biosciences by investing billions of dollars and collecting vast amounts of genetic data from its 1.4 billion population.

Steph Batalis, Caroline Schuerger and Vikram Venkatram explore three notable areas in the life sciences where LLMs are catalyzing meaningful advances: drug discovery, genetics, and precision medicine.