Gain- and loss-of-function research have contributed to breakthroughs in vaccine development, genetic research, and gene therapy. At the same time, a subset of gain- and loss-of-function studies involve high-risk, highly virulent pathogens that could spread widely among humans if deliberately or unintentionally released. In this report, we map the gain- and loss-of-function global research landscape using a quantitative approach that combines machine learning with subject-matter expert review.

This brief examines trends in patents generated through federally funded research, otherwise known as Bayh-Dole patents. We find that while Bayh-Dole patents make up a small proportion of U.S. patents overall, they are much more common in certain fields, especially in biosciences and national defense related fields. Academic institutions are major recipients of Bayh-Dole patents, and the funding landscape for patent-producing research has shifted since Bayh-Dole came into effect in 1980.

This data brief examines South Korea’s progress in its development of artificial intelligence. The authors find that the country excels in semiconductor manufacturing, is a global leader in the production of AI patents, and is an important contributor to AI research. At the same time, the AI investment ecosystem remains nascent and despite having a highly developed AI workforce, the demand for AI talent may soon outpace supply.

CSET submitted the following comment in response to a Request for Information (RFI) from the National Science Foundation (NSF) about the development of the newly established Technology, Innovation, and Partnerships (TIP) Directorate, in accordance with the CHIPS and Science Act of 2022.

Vaccines keep the U.S. public healthy while safeguarding economic stability and biosecurity. This report assesses the domestic vaccine manufacturing landscape and identifies two major vulnerabilities: a reliance on foreign manufacturers and a lack of manufacturing redundancy. Maintaining a resilient vaccine supply will require the U.S. government to take steps to protect the existing supply, identify and monitor manufacturing vulnerabilities, and create a stronger domestic production base.

Israel has by far the largest AI ecosystem in the Middle East as measured in AI companies and financial investments, and foreign investors play a critical role in Israel’s AI market growth. This issue brief finds that AI investments in Israel have mostly originated from the United States. To date, Chinese investors have played a limited role in funding Israel’s dynamic AI companies. But understanding the risk of Chinese investments into the Israeli AI ecosystem will be important for the national security of both the United States and Israel.

Pandemic threats are increasing as globalization, urbanization, and encroachment on animal habitats cause infectious outbreaks to become more frequent and severe. It is imperative that the United States build a pipeline of medical countermeasure development, beginning with basic scientific research and culminating in approved therapies. This report assesses preparedness for families of viral pathogens of pandemic potential and offers recommendations for steps the U.S. government can take to prepare for future pandemics.

China’s government has pushed the country’s technology and financial firms to expand abroad, and Southeast Asia’s growing economies — and AI companies — offer promising opportunities. This report examines the scope and nature of Chinese investment in the region. It finds that China currently plays a limited role in Southeast Asia’s emerging AI markets outside of Singapore and that Chinese investment activity still trails behind that of the United States. Nevertheless, Chinese tech companies, with support from the Chinese government, have established a broad range of other AI-related linkages with public and commercial actors across Southeast Asia.

U.S. policymakers are increasingly concerned about the national security implications of U.S. investments in China, and some are considering a new regime for reviewing outbound investment security. The authors identify the main U.S. investors active in the Chinese artificial intelligence market and the set of AI companies in China that have benefitted from U.S. capital. They also recommend next steps for U.S. policymakers to better address the concerns over capital flowing into the Chinese AI ecosystem.

CSET Non-Resident Senior Fellow Kevin Wolf testified before the Senate Banking Committee on U.S. export control policy and opportunities.