Recent government directives, international conferences, and media headlines reflect growing concern that artificial intelligence could exacerbate biological threats. When it comes to biorisk, AI tools are cited as enablers that lower information barriers, enhance novel biothreat design, or otherwise increase a malicious actor’s capabilities. In this explainer, CSET Biorisk Research Fellow Steph Batalis summarizes the state of the biorisk landscape with and without AI.

CSET submitted the following comment in response to a Request for Comment (RFC) from the Office of Management and Budget (OMB) about a draft memorandum providing guidance to government agencies regarding the appointment of Chief AI Officers, Risk Management for AI, and other processes following the October 30, 2023 Executive Order on AI.

Antimicrobial resistance (AMR) is one of the world’s most pressing global health threats. Basic research is the first step towards identifying solutions. This brief examines the AMR research landscape since 2000, finding that the amount of research is increasing and that the U.S. is a leading publisher, but also that novel solutions like phages and synthetic antimicrobial production are a small portion of that research.

CSET submitted the following comment in response to a Request for Information (RFI) from the White House's Office of Science and Technology Policy about potential changes to the Policies for Federal and Institutional Oversight of Life Sciences Dual Use Research of Concern (DURC) and Recommended Policy Guidance for Departmental Development of Review Mechanisms for Potential Pandemic Pathogen Care and Oversight (P3CO).

This report summarizes more than 20 CSET reports, translations, and data analyses to provide insight into the steps China has taken to increase its technological competitiveness beyond its own borders.

This report summarizes more than 20 CSET reports, translations, and data analyses to provide insight into China’s internal actions to advance and implement its technology-related policy goals

CSET Senior Fellow Anna Puglisi testifies before the Senate Energy and Natural Resources Committee on the DOE lab complex and the research security threats it faces.

Translation Snapshots are short posts that highlight related translations produced by CSET’s in-house translation team. Each snapshot identifies relevant translations, provides short summaries, and links to the full translations. Check back regularly for additional Translation Snapshots highlighting our work.

Gain- and loss-of-function research have contributed to breakthroughs in vaccine development, genetic research, and gene therapy. At the same time, a subset of gain- and loss-of-function studies involve high-risk, highly virulent pathogens that could spread widely among humans if deliberately or unintentionally released. In this report, we map the gain- and loss-of-function global research landscape using a quantitative approach that combines machine learning with subject-matter expert review.

CSET submitted the following comment in response to a Request for Information (RFI) from the National Science Foundation (NSF) about the development of the newly established Technology, Innovation, and Partnerships (TIP) Directorate, in accordance with the CHIPS and Science Act of 2022.