We appreciate the opportunity to provide feedback to the U.S. Artificial Intelligence Safety Institute (AISI) regarding future practices for the responsible development and use of chemical and biological (chem-bio) AI models. Our research at the Center for Security and Emerging Technology (CSET) at Georgetown University examines the convergence of AI and biotechnology and its impact on U.S. national, economic, and health security. As the RFI notes, AI tools present exciting possibilities for biomedical research and scientific innovation. At the same time, these same tools have raised concerns about their potential to contribute to biological threats. 

Our work, including our newest report, examines many of the questions posed by this RFI. Anticipating Biorisk: A Toolkit for Strategic Biosecurity Policy describes the different ways that pathogens or toxins can cause harmful outcomes, and the measures policymakers can implement to mitigate those risks.¹

1. Batalis, Steph. “Anticipating Biological Risk: A Toolkit for Strategic Biosecurity Policy.” Center for Security and Emerging Technology, December 3, 2024. https://cset.georgetown.edu/publication/anticipating-biological-risk-a-toolkit-for-strategic-biosecurity-policy/.