Bio-Risk

CSET's Anna Puglisi was cited in an article by CNN that delves into China's efforts to become a global leader in the biosciences by investing billions of dollars and collecting vast amounts of genetic data from its 1.4 billion population.

Large Language Models in Biology

Steph Batalis, Caroline Schuerger, and Vikram Venkatram
| June 16, 2023

Steph Batalis, Caroline Schuerger and Vikram Venkatram explore three notable areas in the life sciences where LLMs are catalyzing meaningful advances: drug discovery, genetics, and precision medicine.

A Shot of Resilience

Steph Batalis and Anna Puglisi
| May 2023

Vaccines keep the U.S. public healthy while safeguarding economic stability and biosecurity. This report assesses the domestic vaccine manufacturing landscape and identifies two major vulnerabilities: a reliance on foreign manufacturers and a lack of manufacturing redundancy. Maintaining a resilient vaccine supply will require the U.S. government to take steps to protect the existing supply, identify and monitor manufacturing vulnerabilities, and create a stronger domestic production base.

Viral Families and Disease X: A Framework for U.S. Pandemic Preparedness Policy

Caroline Schuerger, Steph Batalis, Katherine Quinn, Amesh Adalja, and Anna Puglisi
| April 2023

Pandemic threats are increasing as globalization, urbanization, and encroachment on animal habitats cause infectious outbreaks to become more frequent and severe. It is imperative that the United States build a pipeline of medical countermeasure development, beginning with basic scientific research and culminating in approved therapies. This report assesses preparedness for families of viral pathogens of pandemic potential and offers recommendations for steps the U.S. government can take to prepare for future pandemics.

Dashing for the Double Helix

Politico
| March 9, 2023

CSET Director of Biotechnology Programs and Senior Fellow Anna Puglisi provided insights into China's illicit efforts to acquire genetic data from the United States in Politico's Morning Cybersecurity. She pointed out that such data will serve a wide variety of interests, from health care to agriculture. “It’s enablers like sequencing and other tools of discovery that are going to drive the bioeconomy, that are going to drive precision medicine,” she said. “The more data you have, the more you can start to understand what genes do.”

Comment to the National Biotechnology and Biomanufacturing Initiative

Caroline Schuerger, Steph Batalis, and Vikram Venkatram
| January 20, 2023

CSET's Dr. Caroline Schuerger, Dr. Steph Batalis, and Vikram Venkatram submitted this comment with recommendations for the National Biotechnology and Biomanufacturing Initiative.

CSET's Anna Puglisi and Andrew Imbrie discuss actions democracies can take to shape the development of biotechnology.

CSET hosted a discussion with Dr. Amesh Adalja, Senior Scholar at the Johns Hopkins University Center for Health Security, on the importance of understanding the breadth and depth of global biological activity in preparing for future pandemics.

Mapping Biosafety Level-3 Laboratories by Publications

Caroline Schuerger, Sara Abdulla, and Anna Puglisi
| August 2022

Biosafety Level-3 laboratories (BSL-3) are an essential part of research infrastructure and are used to develop vaccines and therapies. The research conducted in them provides insights into host-pathogen interactions that may help prevent future pandemics. However, these facilities also potentially pose a risk to society through lab accidents or misuse. Despite their importance, there is no comprehensive list of BSL-3 facilities, or the institutions in which they are housed. By systematically assessing PubMed articles published in English from 2006-2021, this paper maps institutions that host BSL-3 labs by their locations, augmenting current knowledge of where high-containment research is conducted globally.

China’s Industrial Clusters

Anna Puglisi and Daniel Chou
| June 2022

China is banking on applying AI to biotechnology research in order to transform itself into a “biotech superpower.” In pursuit of that goal, it has emphasized bringing together different aspects of the development cycle to foster multidisciplinary research. This data brief examines the emerging trend of co-location of AI and biotechnology researchers and explores the potential impact it will have on this growing field.