Publications

CSET produces evidence-driven analysis in a variety of forms, from informative graphics and translations to expert testimony and published reports. Our key areas of inquiry are the foundations of artificial intelligence — such as talent, data and computational power — as well as how AI can be used in cybersecurity and other national security settings. We also do research on the policy tools that can be used to shape AI’s development and use, and on biotechnology.

Analysis

Understanding the Global Gain-of-Function Research Landscape

Caroline Schuerger Steph Batalis Katherine Quinn Ronnie Kinoshita Owen Daniels Anna Puglisi
| August 2023

Gain- and loss-of-function research have contributed to breakthroughs in vaccine development, genetic research, and gene therapy. At the same time, a subset of gain- and loss-of-function studies involve high-risk, highly virulent pathogens that could spread widely among humans if deliberately or unintentionally released. In this report, we map the gain- and loss-of-function global research landscape using a quantitative approach that combines machine learning with subject-matter expert review.

Bio-Risk


Data


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